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References Royal College of Midwives and Royal College of Obstetricians and Gynaecologists
Finally, following recent concerns by regulatory agencies regarding a potential increase in suicidal behavior associated with GLP-1RAs 206 , we found 1 recent pharmacovigilance report showing 0.6% suicidal events among 41,236 safety reports for these medications 207 and an emulated target trial of 86,418 older adults with T2DM that did not identify any difference in suicidal ideation or behavior between GLP-1RAs and other antidiabetic medications over 1.5 years 208
Indeed, in accordance with the literature, primary cells bearing mutations in Keap1 and/or Tp53 genes were more resistant to RSL3 as compared to cultures without these mutations [14, 22]
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